Supported by CCR Office of Science and Technology Resources (OSTR)

GeoMx Digital Spatial Profiling (DSP)


Biomarker Discovery with Morphological Context

Changing how tissue specimens are analyzed

What is Digital Spatial Profiling?

GeoMx Digital Spatial Profiler is a novel platform developed by NanoString. Digital Spatial Profiling is based on nCounter® barcoding technology and enables spatially resolved, digital readout of up to 96 proteins or RNA targets in a multiplexed assay. The assay relies upon antibody or RNA probes coupled to photocleavable oligonucleotide tags. After hybridization of probes to slide-mounted formalin fixed paraffin-embedded (FFPE) tissue sections, the oligonucleotide tags are released from discrete regions of the tissue via UV exposure. Released tags are quantitated in a standard nCounter assay, and counts are mapped back to tissue location, yielding a spatially-resolved digital profile of analyte abundance.

Project Support

To get more information or to discuss a project, please contact Noemi Kedei, M.D., Facility Head

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